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PMID: 11779478 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells.

Neuron ·Vol. 33 ·No. 1 ·2002-01-03 ·Pages 35-46

Suh GS, Poeck B, Chouard T, Oron E, Segal D, Chamovitz DA, Zipursky SL

Abstract

Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia. The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation.

MeSH Terms

Alleles Animals Body Patterning/genetics COP9 Signalosome Complex Cell Communication/genetics Cell Differentiation/genetics Cell Division/genetics Cell Movement/genetics Chemotaxis/genetics DNA-Binding Proteins/deficiency,genetics Drosophila Proteins Drosophila melanogaster/cytology,embryology,metabolism Embryonic Induction/genetics Female Gene Expression Regulation, Developmental/physiology Genotype Growth Cones/metabolism,ultrastructure Intracellular Signaling Peptides and Proteins Male Mosaicism/genetics Multiprotein Complexes Mutation, Missense/physiology Neuroglia/cytology,metabolism Neuropil/cytology,metabolism Optic Lobe, Nonmammalian/cytology,embryology,metabolism Peptide Hydrolases Photoreceptor Cells, Invertebrate/cytology,embryology,metabolism Proteins/genetics,metabolism Transcription Factors/deficiency,genetics Visual Pathways/cytology,embryology,metabolism

Chemicals

DNA-Binding Proteins Drosophila Proteins Intracellular Signaling Peptides and Proteins Multiprotein Complexes Proteins Transcription Factors Peptide Hydrolases CSN5 protein, Drosophila COP9 Signalosome Complex

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Suh Greg S B

Department of Biological Chemistry, Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles, CA 90095, USA.

Poeck Burkhard

Chouard Tanguy

Oron Efrat

Segal Daniel

Chamovitz Daniel A

Zipursky S Lawrence

Article Info

Journal

Neuron

Abbr.

Neuron

ISSN

0896-6273

DOI

10.1016/s0896-6273(01)00576-1

Published

2002-01-03

Pages

35-46

Language

English

Region

United States

NLM ID

8809320

Subset

External Links

PubMed source DOI: 10.1016/s0896-6273(01)00576-1 View journal details

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Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells.

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