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题目:: [The significance of CD3/MIB1 and CD3/CD25 in B cell lymphomas].
作者:: Wang(J),Zhang(J),Sun(Y)
状态:: 发布时间2002-01-07 , 更新时间 2015-11-19
期刊:: Zhonghua Zhong Liu Za Zhi
摘要:: To identify the distribution and significance of proliferating T cells (PTC) in normal tonsil and a group of B cell lymphomas.,Double immunohistochemical staining was used to detect PTC with MIB1 expression. Giemsa staining was used to detect Helicobacter pylori (Hp) in gastric MALT-type lymphoma. Cell culture was applied to investigate the relationship among tumor cells, Hp and T cells.,Very few T cells expressed MIB1 in the follicular centre of normal tonsil and in that of follicular lymphoma. PTC were mainly distributed to the extrafollicular and T cell zones. So did CD3+ T cells expressed CD25. In low grade primary B cell gastric MALT-type lymphomas, tumor cells proliferated in vitro in response to Hp but died in the absence of T cells. PTC increased with increase in the degree of malignancy in different kinds of B cell lymphomas.,T cells in follicular centres of follicular lymphoma are not in cell cycle. Proliferation of neoplastic B cells in low grade gastric MALT-type lymphomas requires Hp-specific infiltrating T cells. Transformation from low to high grade lymphoma is associated with an increase in T cell activation. T cells expressing MIB1 might be related to prognosis.
语言:: chi
DOI:

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