Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.

Animals Apoptosis Autoimmune Diseases/genetics,immunology,pathology Autoimmunity/genetics,immunology Cell Cycle Proteins Cell Division Chimera Clonal Deletion DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F2 Transcription Factor Gene Expression Regulation/immunology Glomerulonephritis, Membranoproliferative/genetics,immunology H-Y Antigen/genetics,immunology Humans Immunologic Memory Inflammation Jurkat Cells Lymphocyte Activation Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mutagenesis, Site-Directed Receptors, Antigen, T-Cell/immunology Recombinant Fusion Proteins/immunology Repressor Proteins/genetics,physiology S Phase/genetics Self Tolerance/genetics,immunology Splenomegaly/genetics,immunology T-Lymphocytes/cytology,immunology,pathology Thymus Gland/immunology,pathology Transcription Factors/biosynthesis,deficiency,genetics,physiology Transfection

Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F1 protein, human E2F2 Transcription Factor E2F2 protein, human E2f1 protein, mouse H-Y Antigen Receptors, Antigen, T-Cell Recombinant Fusion Proteins Repressor Proteins Transcription Factors