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PMID: 11752696 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity.

The Journal of general virology ·Vol. 83 ·No. Pt 1 ·2002-01-00 ·Pages 11-23

Curran R, Jameson CL, Craggs JK, Grabowska AM, Thomson BJ, Robins A, Irving WL, Ball JK

Abstract

Hepatitis C virus (HCV) exists as a complex swarm of genetically related viruses known as a quasispecies. Recent work has shown that quasispecies complexity and evolutionary rates are associated with the outcome of acute infection. Knowledge of how the virus population evolves at different stages of chronic infection is less clear. We have studied rates of evolution of the first hypervariable region (HVR1) of the E2 envelope protein in six individuals with disparate liver disease severity. These data show that virus populations present in individuals with mild non-progressive liver disease evolve in a typical Darwinian fashion, with a consistent accumulation of non-synonymous (amino acid-changing) substitutions. By contrast, the virus population remains relatively static in individuals with severe progressive liver disease. Possible mechanisms for this disparity are discussed.

MeSH Terms

Alanine Transaminase/metabolism Amino Acids Base Sequence Binding Sites Evolution, Molecular Genetic Variation Hepacivirus/classification,genetics Hepatitis C/metabolism,physiopathology,virology Hepatitis C Antigens/classification,genetics Hepatitis C, Chronic/metabolism,physiopathology,virology Humans Liver/metabolism,physiopathology,virology Liver Diseases/metabolism,physiopathology,virology Molecular Sequence Data Mutagenesis Nucleotides Phylogeny Protein Sorting Signals Sequence Analysis, DNA Viral Envelope Proteins/classification,genetics Viral Load

Chemicals

Amino Acids Hepatitis C Antigens Nucleotides Protein Sorting Signals Viral Envelope Proteins glycoprotein E2, Hepatitis C virus Alanine Transaminase

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Curran Rebecca

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Jameson Claire L

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Craggs Joanna K

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Grabowska Anna M

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Thomson Brian J

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Robins Adrian

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Irving William L

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Ball Jonathan K

Division of Microbiology and Infectious Diseases, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK1.

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-83-1-11

Published

2002-01-00

Pages

11-23

Language

English

Region

England

NLM ID

0077340

Subset

IM

Databases

GENBANK

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External Links

PubMed source DOI: 10.1099/0022-1317-83-1-11 View journal details

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