Adiponectin, metabolic risk factors, and cardiovascular eve…

Abstract

Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro. Among human subjects, plasma ADPN concentrations are reduced among patients with atherosclerotic complications but are substantially increased among patients with advanced renal failure. The clinical and biochemical correlates of plasma ADPN levels were investigated and the predictive power of ADPN levels with respect to survival rates and cardiovascular events was prospectively tested in a cohort of 227 hemodialysis patients, who were monitored for 31 +/- 13 mo. Plasma ADPN levels were 2.5 times higher (P < 0.0001) among dialysis patients (15.0 +/- 7.7 microg/ml) than among healthy subjects (6.3 +/- 2.0 microg/ml), were independent of age, and were higher (P = 0.03) among women (15.2 +/- 7.9 microg/ml) than among men (14.0 +/- 7.4 microg/ml). For both genders, plasma ADPN levels were inversely related to body mass index values, plasma leptin levels, insulin levels, serum triglyceride levels, and homeostatic model assessment index values. Furthermore, plasma ADPN levels were directly related to HDL cholesterol levels and inversely related to von Willebrand factor levels. Plasma ADPN levels were lower (P < 0.05) among patients who experienced new cardiovascular events (13.7 +/- 7.3 microg/ml) than among event-free patients (15.8 +/- 7.8 microg/ml). There was a 3% risk reduction for each 1 microg/ml increase in plasma ADPN levels, and the relative risk of adverse cardiovascular events was 1.56 times (95% confidence interval, 1.12 to 1.99 times) higher among patients in the first ADPN tertile, compared with those in the third tertile. Plasma ADPN levels are an inverse predictor of cardiovascular outcomes among patients with end-stage renal disease. Furthermore, ADPN is related to several metabolic risk factors in a manner consistent with the hypothesis that this protein acts as a protective factor for the cardiovascular system.

MeSH Terms

Adiponectin Aged Cardiovascular Diseases/etiology,mortality Erythropoietin/therapeutic use Female Humans Intercellular Signaling Peptides and Proteins Kidney Failure, Chronic/complications,metabolism,mortality,therapy Male Middle Aged Proteins/metabolism Renal Dialysis Risk Factors Survival Analysis

Chemicals

Adiponectin Intercellular Signaling Peptides and Proteins Proteins Erythropoietin

Authors & Affiliations

18 authors, click to expand affiliations / ORCID

Zoccali Carmine

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Mallamaci Francesca

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Tripepi Giovanni

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Benedetto Francesco A

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Cutrupi Sebastiano

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Parlongo Saverio

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Malatino Lorenzo S

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Bonanno Graziella

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Seminara Giuseppe

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Rapisarda Francesco

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Fatuzzo Pasquale

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Buemi Michele

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Nicocia Giacomo

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Tanaka Sachiyo

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Ouchi Noriyuki

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Kihara Shinji

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Funahashi Tohru

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Matsuzawa Yuji

*National Research Council Center of Clinical Physiology, Reggio Calabria, Italy; Cardiology Division, Ospedale Morelli, Reggio Calabria, Italy; Departments of Internal Medicine and Nephrosurgery and Institute of Internal Medicine and Geriatry, Catania University, Catania, Italy; Clinical Pathology and Nephrology Units, University of Messina, Messina, Italy; and Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease.

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