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PMID: 11733553 Published · ppublish English Comment Journal Article Research Support, Non-U.S. Gov't

Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis.

The Journal of clinical investigation ·Vol. 108 ·No. 11 ·2001-12-00 ·Pages 1583-7

Kerjaschki D

Abstract

暂无摘要

MeSH Terms
Actins/chemistry Adaptor Proteins, Signal Transducing Cytoskeletal Proteins Epithelial Cells/pathology Glomerulosclerosis, Focal Segmental/etiology Humans Intracellular Signaling Peptides and Proteins Kidney Glomerulus/pathology Membrane Proteins/chemistry Proteins/chemistry
Chemicals
Actins Adaptor Proteins, Signal Transducing CD2-associated protein Cytoskeletal Proteins Intracellular Signaling Peptides and Proteins Membrane Proteins NPHS2 protein Proteins nephrin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kerjaschki D
Department of Pathology, University of Vienna-Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria. dontscho.kerjaschki@akh-wien.ac.at
References (38)
38 references, click to expand
  1. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats.
    J Exp Med. 1983 Feb 1;157(2):667-86 PMID: 6337231
  2. An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus.
    J Exp Med. 1957 Nov 1;106(5):649-60 PMID: 13475621
  3. Identification and characterization of podocalyxin--the major sialoprotein of the renal glomerular epithelial cell.
    J Cell Biol. 1984 Apr;98(4):1591-6 PMID: 6371025
  4. Regional heterogeneity of glycoconjugate distribution in the glomerulus revealed by lectin-gold cytochemistry and SDS-PAGE.
    Am J Pathol. 1986 Dec;125(3):601-10 PMID: 2432793
  5. Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.
    Lab Invest. 1988 Nov;59(5):673-82 PMID: 3141719
  6. A beta 1-integrin receptor for fibronectin in human kidney glomeruli.
    Am J Pathol. 1989 Feb;134(2):481-9 PMID: 2521774
  7. Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.
    Cell. 1990 Aug 10;62(3):425-34 PMID: 1696177
  8. Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy.
    J Clin Invest. 1995 Dec;96(6):2809-19 PMID: 8675651
  9. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis.
    Development. 1996 Nov;122(11):3537-47 PMID: 8951069
  10. Induction of differentiation in cultured rat and human podocytes.
    J Am Soc Nephrol. 1997 May;8(5):697-705 PMID: 9176839
  11. Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin.
    J Biol Chem. 1997 Jun 20;272(25):15708-14 PMID: 9188463
  12. Reactive oxygen species cause direct damage of Engelbreth-Holm-Swarm matrix.
    Am J Pathol. 1997 Jul;151(1):215-31 PMID: 9212747
  13. Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.
    J Clin Invest. 1997 Nov 1;100(9):2303-9 PMID: 9410908
  14. Bidirectional signaling between sarcoglycans and the integrin adhesion system in cultured L6 myocytes.
    J Biol Chem. 1998 Jan 16;273(3):1583-90 PMID: 9430699
  15. Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy.
    Am J Pathol. 1999 Apr;154(4):1067-75 PMID: 10233845
  16. Dystroglycan inside and out.
    Curr Opin Cell Biol. 1999 Oct;11(5):602-7 PMID: 10508656
  17. Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.
    J Am Soc Nephrol. 1999 Nov;10(11):2440-5 PMID: 10541305
  18. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin.
    J Clin Invest. 1999 Dec;104(11):1559-66 PMID: 10587519
  19. The glomerular slit diaphragm is a modified adherens junction.
    J Am Soc Nephrol. 2000 Jan;11(1):1-8 PMID: 10616834
  20. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis.
    J Am Soc Nephrol. 2000 Mar;11(3):403-12 PMID: 10703664
  21. Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells.
    J Am Soc Nephrol. 2000 Mar;11(3):413-22 PMID: 10703665
  22. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.
    Nat Genet. 2000 Apr;24(4):349-54 PMID: 10742096
  23. Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies.
    Am J Pathol. 2000 May;156(5):1749-65 PMID: 10793086
  24. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate.
    J Clin Invest. 2000 Nov;106(10):1281-90 PMID: 11086029
  25. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.
    Hum Mol Genet. 2001 Jan 1;10(1):1-8 PMID: 11136707
  26. FAT is a component of glomerular slit diaphragms.
    Kidney Int. 2001 Mar;59(3):1003-12 PMID: 11231355
  27. The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.
    J Am Soc Nephrol. 2001 Apr;12(4):667-77 PMID: 11274227
  28. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.
    Mol Cell Biol. 2001 Jul;21(14):4829-36 PMID: 11416156
  29. Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.
    J Exp Med. 2001 Jul 2;194(1):13-27 PMID: 11435469
  30. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton.
    J Clin Invest. 2001 Jul;108(2):289-301 PMID: 11457882
  31. Integrin-linked kinase as a candidate downstream effector in proteinuria.
    FASEB J. 2001 Aug;15(10):1843-5 PMID: 11481249
  32. Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm.
    Am J Pathol. 2001 Sep;159(3):1069-77 PMID: 11549599
  33. CD2AP and p130Cas localize to different F-actin structures in podocytes.
    Am J Physiol Renal Physiol. 2001 Oct;281(4):F769-77 PMID: 11553524
  34. Structure of Arp2/3 complex in its activated state and in actin filament branch junctions.
    Science. 2001 Sep 28;293(5539):2456-9 PMID: 11533442
  35. Interaction with podocin facilitates nephrin signaling.
    J Biol Chem. 2001 Nov 9;276(45):41543-6 PMID: 11562357
  36. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.
    J Clin Invest. 2001 Dec;108(11):1621-9 PMID: 11733557
  37. Transport of molecules across renal glomerular capillaries.
    Physiol Rev. 1976 Jul;56(3):502-34 PMID: 778868
  38. Congenital nephrotic syndrome in mice lacking CD2-associated protein.
    Science. 1999 Oct 8;286(5438):312-5 PMID: 10514378
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI14629
Email
dontscho.kerjaschki@akh-wien.ac.at
Published
2001-12-00
Pages
1583-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC201002
Subset
IM
Corrections
CommentOn
PMID: 11733557
External Links
PubMed source DOI: 10.1172/JCI14629 PMC Full Text View journal details
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