Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

Neurology ·Vol. 57 ·No. 10 ·2001-11-27 ·Pages 1896-9

Olafsdóttir BR, Rye DB, Scammell TE, Matheson JK, Stefánsson K, Gulcher JR

Abstract

The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.

MeSH Terms

Adult Carrier Proteins/genetics Chromosome Mapping Cross-Cultural Comparison Exons Female Genetic Predisposition to Disease/genetics Genetic Testing Genotype Humans Iceland Intracellular Signaling Peptides and Proteins Introns Male Middle Aged Narcolepsy/diagnosis,genetics Neuropeptides/genetics Orexin Receptors Orexins Polymorphism, Genetic Protein Precursors/genetics Receptors, G-Protein-Coupled Receptors, Neuropeptide/genetics United States

Chemicals

Carrier Proteins Intracellular Signaling Peptides and Proteins Neuropeptides Orexin Receptors Orexins Protein Precursors Receptors, G-Protein-Coupled Receptors, Neuropeptide

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Olafsdóttir B R

deCODE genetics Inc, Reykjavík, Iceland.

Rye D B

Scammell T E

Matheson J K

Stefánsson K

Gulcher J R

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

0028-3878

DOI

10.1212/wnl.57.10.1896

Published

2001-11-27

Pages

1896-9

Language

English

Region

United States

NLM ID

0401060

Subset

External Links

PubMed source DOI: 10.1212/wnl.57.10.1896 View journal details

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Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

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