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PMID: 11707590 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Diversity of gene expression in adenocarcinoma of the lung.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 24 ·2001-11-20 ·Pages 13784-9

Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, Altman RB, Brown PO, Botstein D, Petersen I

Abstract

The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

MeSH Terms
Adenocarcinoma/classification,genetics,mortality,pathology Carcinoma, Large Cell/classification,genetics Carcinoma, Small Cell/classification,genetics Carcinoma, Squamous Cell/classification,genetics Gene Expression Gene Expression Profiling Genetic Variation Humans Lung Neoplasms/classification,genetics,mortality,pathology Survival Rate/trends
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Garber M E
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Troyanskaya O G
Schluens K
Petersen S
Thaesler Z
Pacyna-Gengelbach M
van de Rijn M
Rosen G D
Perou C M
Whyte R I
Altman R B
Brown P O
Botstein D
Petersen I
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.241500798
Published
2001-11-20
Epub
2001-00-13
Pages
13784-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC61119
Subset
IM
Grants
NCI NIH HHS · R01 CA077097 · United States
NCI NIH HHS · U01 CA085129 · United States
NCI NIH HHS · CA77097 · United States
NCI NIH HHS · CA85129 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1073/pnas.241500798 PMC Full Text View journal details
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