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PMID: 11699948 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Purinergic signalling: ATP release.

Neurochemical research ·Vol. 26 ·No. 8-9 ·2001-09-00 ·Pages 959-69

Bodin P, Burnstock G

Abstract

Adenosine triphosphate (ATP) has a fundamental intracellular role as the universal source of energy for all living cells. The demonstration of its release into the extracellular space and the identification and localisation of specific receptors on target cells have been essential in establishing, after considerable resistance, its extracellular physiological roles. It is now generally accepted that ATP is a genuine neurotransmitter both in the central and peripheral nervous systems. As such, there are numerous arguments which prove that the release of ATP by nerve terminals is by exocytosis. In some non-neuronal cells, however, recent evidence suggests that ATP release could also be carrier-mediated and would involve ATP-binding cassette proteins (ABC), an ubiquitous family of transport ATPases.

MeSH Terms
Adenosine Triphosphate/metabolism Animals Signal Transduction
Chemicals
Adenosine Triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bodin P
Autonomic Neuroscience Institute, Royal Free and University College School of Medicine, University College London, UK.
Burnstock G
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1023/a:1012388618693
Published
2001-09-00
Pages
959-69
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1012388618693 View journal details
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