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PMID: 11687813 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Internalization of ionotropic glutamate receptors in response to mGluR activation.

Nature neuroscience ·Vol. 4 ·No. 11 ·2001-11-00 ·Pages 1079-85

Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, Bear MF

Abstract

Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.

MeSH Terms

Amino Acids/pharmacology Animals Cells, Cultured Cycloheximide/pharmacology Dendrites/metabolism Electrophysiology Endocytosis/physiology Excitatory Amino Acid Antagonists/pharmacology Excitatory Postsynaptic Potentials/physiology Glycine/analogs & derivatives,pharmacology Hippocampus/cytology Immunohistochemistry In Vitro Techniques Methoxyhydroxyphenylglycol/analogs & derivatives Neurons/drug effects,metabolism Protein Synthesis Inhibitors/pharmacology Rats Rats, Long-Evans Receptors, AMPA/metabolism Receptors, Metabotropic Glutamate/metabolism Receptors, N-Methyl-D-Aspartate/metabolism Resorcinols/pharmacology Synapses/metabolism Synapsins/metabolism Synaptic Transmission/drug effects Xanthenes/pharmacology

Chemicals

Amino Acids Excitatory Amino Acid Antagonists LY 341495 Protein Synthesis Inhibitors Receptors, AMPA Receptors, Metabotropic Glutamate Receptors, N-Methyl-D-Aspartate Resorcinols Synapsins Xanthenes Methoxyhydroxyphenylglycol 3,5-dihydroxyphenylglycine Cycloheximide Glycine 3,4-dihydroxyphenylglycol

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Snyder E M

Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.

Philpot B D

Huber K M

Dong X

Fallon J R

Bear M F

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/nn746

Published

2001-11-00

Pages

1079-85

Language

English

Region

United States

NLM ID

9809671

Subset

Grants

NINDS NIH HHS · NS39321 · United States

NINDS NIH HHS · P01 NS039321 · United States

NCRR NIH HHS · P20 RR015578 · United States

NINDS NIH HHS · P01 NS039321-03 · United States

NCRR NIH HHS · P20 RR015578-020002 · United States

External Links

PubMed source DOI: 10.1038/nn746 View journal details

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Internalization of ionotropic glutamate receptors in response to mGluR activation.

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