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PMID: 11684441 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.

Trends in cell biology ·Vol. 11 ·No. 11 ·2001-11-00 ·Pages S37-43

Chang C, Werb Z

Abstract

Metalloproteases are important in many aspects of biology, ranging from cell proliferation, differentiation and remodeling of the extracellular matrix (ECM) to vascularization and cell migration. These events occur several times during organogenesis in both normal development and during tumor progression. Mechanisms of metalloprotease action underlying these events include the proteolytic cleavage of growth factors so that they can become available to cells not in direct physical contact, degradation of the ECM so that founder cells can move across tissues into nearby stroma, and regulated receptor cleavage to terminate migratory signaling. Most of these processes require a delicate balance between the functions of matrix metalloproteases (MMPs) or metalloprotease-disintegrins (ADAMs) and natural tissue inhibitors of metalloproteases (TIMPs). In this review, we discuss recent progress in identifying an essential role for metalloproteases in axon outgrowth, as an example of a focal invasive event. We also discuss the evolving concept of how MMPs might regulate stem cell fate during tumor development.

MeSH Terms
Animals Axons/physiology Cell Division/physiology Extracellular Matrix/metabolism Growth Substances/metabolism Humans Matrix Metalloproteinases/metabolism Neoplasm Invasiveness Neoplasm Metastasis Neoplasms/pathology,physiopathology Neovascularization, Pathologic Protease Inhibitors/metabolism Tissue Inhibitor of Metalloproteinases/metabolism
Chemicals
Growth Substances Protease Inhibitors Tissue Inhibitor of Metalloproteinases Matrix Metalloproteinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chang C
Department of Anatomy, Box 0452, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA.
Werb Z
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
0962-8924
DOI
10.1016/s0962-8924(01)02122-5
Published
2001-11-00
Pages
S37-43
Language
English
Region
England
NLM ID
9200566
PMCID
PMC2788992
Subset
IM
Grants
NINDS NIH HHS · R01 NS039278 · United States
NCI NIH HHS · P01 CA 72006 · United States
NINDS NIH HHS · R01 NS 39278 · United States
NIEHS NIH HHS · T32 ES 07106 · United States
NIAMS NIH HHS · R01 AR046238-07 · United States
NCI NIH HHS · P01 CA072006-040003 · United States
NINDS NIH HHS · R01 NS039278-01 · United States
NIAMS NIH HHS · AR 46238 · United States
NIEHS NIH HHS · T32 ES007106 · United States
NIEHS NIH HHS · T32 ES007106-17 · United States
NIAMS NIH HHS · R01 AR046238 · United States
NCI NIH HHS · P01 CA072006 · United States
External Links
PubMed source DOI: 10.1016/s0962-8924(01)02122-5 PMC Full Text View journal details
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