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PMID: 1167605 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Alterations in Sindbis viral enbelope proteins by treating BHK cells with glucosamine.

Journal of virology ·Vol. 15 ·No. 2 ·1975-02-00 ·Pages 416-9

Duda E, Schlesinger MJ

Abstract

Addition of d-glucosamine to BHK cells infected with Sindbis virus inhibited the formation of the E-2 viral envelope from its precursor PE-2. Release of virus was blocked, and two new viral protein bands replaced the normal envelope protein bands detected in SDS-gel electropherograms of infected cell extracts.

MeSH Terms

Animals Autoradiography Cell Line Cell Membrane/drug effects Cricetinae Electrophoresis, Polyacrylamide Gel Glucosamine/pharmacology Kidney Methionine/metabolism Molecular Weight Peptide Biosynthesis Sindbis Virus/immunology,metabolism Sulfur Radioisotopes Viral Proteins/biosynthesis,immunology

Chemicals

Sulfur Radioisotopes Viral Proteins Methionine Glucosamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Duda E

Schlesinger M J

References (16)

16 references, click to expand

Biosynthesis of the Sindbis virus carbohydrates.
J Virol. 1973 Dec;12(6):1366-74 PMID: 4796898
Analysis of bacteriophage T7 early RNAs and proteins on slab gels.
J Mol Biol. 1973 Sep 15;79(2):237-48 PMID: 4760132
Large-molecular-weight precursors of sindbis virus proteins.
J Virol. 1973 Jun;11(6):1013-6 PMID: 4736531
Formation of Sindbis virus proteins: identification of a precursor for one of the envelope proteins.
J Virol. 1972 Nov;10(5):925-32 PMID: 4673887
Morphology and morphogenesis of Sindbis virus as seen with freeze-etching techniques.
J Virol. 1972 Sep;10(3):524-36 PMID: 4672393
Identification of a second glycoprotein in Sindbis virus.
Virology. 1972 Feb;47(2):539-41 PMID: 5058841
Evidence for cell-surface glycosyltransferases. Their potential role in cellular recognition.
J Cell Biol. 1971 Nov;51(21):536-47 PMID: 5165268
Modification of Sindbis virus glycoprotein by host-specified glycosyl transferases.
J Virol. 1971 Mar;7(3):309-13 PMID: 5102426
Kinetics of incorporation of structural proteins into Sindbis virions.
J Virol. 1969 Apr;3(4):369-75 PMID: 5771964
PURIFICATION AND PARTIAL CHEMICAL ANALYSIS OF SINDBIS VIRUS.
Virology. 1963 Jul;20:433-45 PMID: 14043407
Inhibition of protein, glycoprotein, ribonucleic acid and deoxyribonucleic acid synthesis by D-glucosamine and other sugars in mouse leukemic cells L5178Y and selective inhibition in SV-3T3 compared with 3T3 cells.
Biochim Biophys Acta. 1971 Jun 17;240(1):74-93 PMID: 4329927
Sindbis virus maturation.
J Gen Virol. 1973 Mar;18(3):375-9 PMID: 4121292
Inhibition of the multiplication of enveloped RNA-viruses by glucosamine and 2-deoxy-D-glucose.
J Gen Virol. 1972 Mar;14(3):251-9 PMID: 4336520
Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.
Virology. 1972 Sep;49(3):723-34 PMID: 4672417
Comparison of membrane protein glycopeptides of Sindbis virus and vesicular stomatitis virus.
J Virol. 1970 Aug;6(2):176-82 PMID: 4322870
Replication of Sindbis virus. 3. An electron microscopic study of virus maturation using the surface replica technique.
Virology. 1973 Dec;56(2):429-38 PMID: 4585892

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.15.2.416-419.1975

Published

1975-02-00

Pages

416-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC354468

Subset

External Links

PubMed source DOI: 10.1128/JVI.15.2.416-419.1975 PMC Full Text View journal details

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Alterations in Sindbis viral enbelope proteins by treating BHK cells with glucosamine.

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