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PMID: 1166069 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) ·Vol. 149 ·No. 4 ·1975-09-00 ·Pages 1026-8

Mihas AA, Gibson RG, Hirschowitz BI

Abstract

A new synthetic prostaglandin (16, 16-PGE2) and unsaturated fatty acids have been shown to inhibit the incorporation of [3H]thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin (PHA). This inhibition was not due to toxicity of these substances, for the lymphocytes remained intact and capable of excluding trypan blue.

MeSH Terms

Adult Arachidonic Acids/pharmacology Dose-Response Relationship, Drug Fatty Acids, Unsaturated/pharmacology Humans Linoleic Acids/pharmacology Lymphocyte Activation/drug effects Oleic Acids/pharmacology Prostaglandins E/pharmacology

Chemicals

Arachidonic Acids Fatty Acids, Unsaturated Linoleic Acids Oleic Acids Prostaglandins E

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mihas A A

Gibson R G

Hirschowitz B I

Article Info

Journal

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Abbr.

Proc Soc Exp Biol Med

ISSN

0037-9727

DOI

10.3181/00379727-149-38949

Published

1975-09-00

Pages

1026-8

Language

English

Region

United States

NLM ID

7505892

Subset

External Links

PubMed source DOI: 10.3181/00379727-149-38949 View journal details

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Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids.

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