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PMID: 11653890 Published · ppublish English Journal Article

The cystic fibrosis gene: medical and social implications for heterozygote detection.

JAMA ·Vol. 263 ·No. 10 ·1990-00-00 ·Pages 2777-83

Wilfond BS, Fost N

Abstract

暂无摘要

Keywords
Analytical Approach Empirical Approach Genetics and Reproduction Health Care and Public Health
MeSH Terms
Abortion, Eugenic Adult Cost-Benefit Analysis Cystic Fibrosis Decision Making Economics Eugenics Evaluation Studies as Topic Federal Government Genetic Counseling Genetic Testing Goals Government Government Regulation Heterozygote Humans Industry Infant, Newborn Informed Consent Mass Screening Physicians Policy Making Prejudice Prenatal Diagnosis Public Policy Reference Standards Reproduction Risk Risk Assessment Social Control, Formal Stereotyping Stress, Psychological United States
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilfond Benjamin S
Fost Norman
Other Abstracts
eng

Heterozygote detection of the cystic fibrosis (CF) gene in the general population now is possible, and there are calls for immediate implementation of mass carrier screening. Given the large number of heterozygote carriers in the United States (approximately 1 in 25 whites), entrepreneurial interest is expected to be strong in what would be this country's most extensive genetic screening program. Wilfond and Fost review past American experiences and problems with mass screening programs for PKU and the sickle cell trait, and assess the potential for similar problems with a carrier screening program for CF. They stress the need for pilot studies before mass CF screening is implemented, and conclude with some procedural recommendations for avoiding the problems that accompanied earlier screening programs for genetic disease.

Article Info
Journal
JAMA
Abbr.
JAMA
ISSN
0098-7484
Published
1990-00-00
Pages
2777-83
Language
English
Region
United States
NLM ID
7501160
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