Rapamycin's resurrection: a new way to target the cancer cell cycle.

Animals Antineoplastic Agents/pharmacology Cell Cycle/drug effects Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Drug Evaluation, Preclinical Drug Industry/organization & administration Genes, Tumor Suppressor Humans Immunosuppressive Agents/pharmacology Neoplasm Proteins/deficiency,genetics,physiology Neoplasms/drug therapy Neoplasms, Experimental/drug therapy PTEN Phosphohydrolase Phosphoric Monoester Hydrolases/deficiency,genetics,physiology Phosphorylation Protein Kinase Inhibitors Protein Kinases/physiology Protein Processing, Post-Translational/drug effects Protein Serine-Threonine Kinases Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins c-akt Signal Transduction/drug effects Sirolimus/analogs & derivatives,pharmacology TOR Serine-Threonine Kinases Tumor Suppressor Proteins/deficiency,genetics,physiology

Antineoplastic Agents Immunosuppressive Agents Neoplasm Proteins Protein Kinase Inhibitors Proto-Oncogene Proteins Tumor Suppressor Proteins temsirolimus Protein Kinases MTOR protein, human Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human Sirolimus