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PMID: 11594459 Published · ppublish English Journal Article Review

Signaling by CD40 and its mimics in B cell activation.

Immunologic research ·Vol. 24 ·No. 2 ·2001-00-00 ·Pages 97-109

Bishop GA, Hostager BS

Abstract

CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has been shown to play important roles in T cell-mediated B lymphocyte activation. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. Several distinct structural motifs in the CD40 cytoplasmic domain regulate various CD40 signaling pathways, which involve both the TNF-R associated factors (TRAFs) and additional signaling proteins, and lead to activation of kinases and transcription factors. CD40-mediated B cell activation is mimicked by several biological response modifiers, as well as by a viral oncoprotein encoded by the Epstein-Barr virus (EBV).

MeSH Terms
Amino Acid Sequence B-Lymphocytes/immunology CD40 Antigens/metabolism Cell Transformation, Neoplastic Lymphocyte Activation Molecular Mimicry Molecular Sequence Data Receptors, Cell Surface/metabolism Receptors, Tumor Necrosis Factor/metabolism Signal Transduction
Chemicals
CD40 Antigens Receptors, Cell Surface Receptors, Tumor Necrosis Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bishop G A
Dept. of Microbiology, The University of Iowa, Iowa City 52242, USA. gail-bishop@uiowa.edu
Hostager B S
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:24:2:097
Email
gail-bishop@uiowa.edu
Published
2001-00-00
Pages
97-109
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1385/IR:24:2:097 View journal details
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