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PMID: 11584296 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

A tour of structural genomics.

Nature reviews. Genetics ·Vol. 2 ·No. 10 ·2001-10-00 ·Pages 801-9

Brenner SE

Abstract

Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is likely to change the use of structure in molecular biology and biochemistry.

MeSH Terms

Amino Acid Sequence Animals Computational Biology/methods,organization & administration Crystallography, X-Ray Databases, Factual Databases, Protein Feasibility Studies Forecasting Genomics/methods Humans Laboratories Models, Molecular Models, Structural Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Pilot Projects Protein Conformation Protein Structure, Tertiary Proteins/chemistry,genetics,isolation & purification Sequence Homology, Amino Acid Structure-Activity Relationship

Chemicals

Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Brenner S E

Department of Plant and Microbial Biology, University of California, 461A Koshland Hall, Berkeley, California 94720-3102, USA. brenner@compbio.berkeley.edu

Article Info

Journal

Nature reviews. Genetics

Abbr.

Nat Rev Genet

ISSN

1471-0056

DOI

10.1038/35093574

brenner@compbio.berkeley.edu

Published

2001-10-00

Pages

801-9

Language

English

Region

England

NLM ID

100962779

Subset

External Links

PubMed source DOI: 10.1038/35093574 View journal details

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