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PMID: 11576673 Published · ppublish English Journal Article Review

Neural activity: sculptor of 'barrels' in the neocortex.

Trends in neurosciences ·Vol. 24 ·No. 10 ·2001-10-00 ·Pages 589-95

Erzurumlu RS, Kind PC

Abstract

A major portion of the primary somatosensory cortex of rodents is characterized by the discrete and patterned distribution of thalamocortical axons and layer IV granule cells ('barrels'), which correspond to the spatial distribution of whiskers and sinus hairs on the snout. In recent years several mutant mouse models began unveiling the cellular and molecular mechanisms by which these patterns emerge presynaptically and are reflected postsynaptically. Neural activity plays a crucial role in conferring presynaptic patterns to postsynaptic cells via neurotransmitter receptor-mediated intracellular signals. Here we review recent evidence that is finally opening the doors to understanding the cellular and molecular mechanisms of pattern formation in the neocortex.

MeSH Terms
Animals Neocortex/physiology Somatosensory Cortex/physiology Vibrissae/innervation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Erzurumlu R S
Department of Cell Biology and Anatomy and Neuroscience Center, LSUHSC, New Orleans, LA 70012, USA. rerzur@lsuhsc.edu
Kind P C
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Article Info
Journal
Trends in neurosciences
Abbr.
Trends Neurosci
ISSN
0166-2236
DOI
10.1016/s0166-2236(00)01958-5
Email
rerzur@lsuhsc.edu
Published
2001-10-00
Pages
589-95
Language
English
Region
England
NLM ID
7808616
PMCID
PMC3722604
Subset
IM
Grants
NINDS NIH HHS · R01 NS039050 · United States
External Links
PubMed source DOI: 10.1016/s0166-2236(00)01958-5 PMC Full Text View journal details
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