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PMID: 11562477 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 20 ·2001-09-25 ·Pages 11708-13

Thompson CL, Blaner WS, Van Gelder RN, Lai K, Quadro L, Colantuoni V, Gottesman ME, Sancar A

Abstract

To investigate the role of retinal-based pigments (opsins) in circadian photoreception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free diet and tested for photic induction of gene expression in the suprachiasmatic nucleus. After 10 months on the vitamin A-free diet, the majority of mice contained no detectable retinal in their eyes. These mice demonstrated fully intact photic signaling to the suprachiasmatic nucleus as measured by acute mPer mRNA induction in the suprachiasmatic nucleus in response to bright or dim light. The data suggest that a non-opsin pigment is the primary circadian photoreceptor in the mouse.

MeSH Terms
Animals Circadian Rhythm/physiology Crosses, Genetic Female Homozygote In Situ Hybridization Male Mice Mice, Inbred C57BL Photoreceptor Cells, Vertebrate/physiology Reference Values Retinaldehyde/physiology Retinol-Binding Proteins/deficiency,genetics,metabolism Retinol-Binding Proteins, Plasma Signal Transduction/physiology Suprachiasmatic Nucleus/physiology,physiopathology Time Factors Vitamin A Deficiency/physiopathology
Chemicals
Retinol-Binding Proteins Retinol-Binding Proteins, Plasma Retinaldehyde
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Thompson C L
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Blaner W S
Van Gelder R N
Lai K
Quadro L
Colantuoni V
Gottesman M E
Sancar A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.201301498
Published
2001-09-25
Epub
2001-00-18
Pages
11708-13
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC58794
Subset
IM
Grants
NEI NIH HHS · EYK0800403 · United States
NEI NIH HHS · EY12858 · United States
NIDDK NIH HHS · DK52444 · United States
NIGMS NIH HHS · GM31082 · United States
NIGMS NIH HHS · R37 GM031082 · United States
NIGMS NIH HHS · R01 GM031082 · United States
External Links
PubMed source DOI: 10.1073/pnas.201301498 PMC Full Text View journal details
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