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PMID: 11553795 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular synapomorphies resolve evolutionary relationships of extant jawed vertebrates.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 20 ·2001-09-25 ·Pages 11382-7

Venkatesh B, Erdmann MV, Brenner S

Abstract

The evolutionary relationships of gnathostomes (jawed vertebrates), which comprise chondrichthyans (cartilaginous fishes), lobe-finned fishes (coelacanths and lungfishes), tetrapods, and actinopterygians (ray-finned fishes), have been debated for almost a century. Phylogenetic analyses based on fossils, morphology, and molecular sequences have generated different models of relationships that remain unresolved. We identified 13 derived shared molecular markers (synapomorphies) that define clades in the vertebrate lineage and used them to resolve the phylogenetic relationships of extant jawed vertebrates. Our markers include the presence or absence of insertions and deletions in coding sequences, nuclear introns, and alternatively spliced transcripts. The synapomorphies identified by us are congruent with each other and give rise to a single phylogenetic tree. This tree confirms that chondrichthyans are basal to all living gnathostomes, that lungfishes (Dipnoi) are the closest living relatives of tetrapods, and that bichirs (Cladistia) are the living members of the most ancient family of ray-finned fishes. Our study also provides molecular evidence to support the monophyly of living tetrapods and teleosts.

MeSH Terms

Amino Acid Sequence Animals Biological Evolution DNA-Binding Proteins/chemistry,genetics Evolution, Molecular Fishes/anatomy & histology,classification,genetics Fossils Genes, RAG-1 Homeodomain Proteins/chemistry,genetics Humans Jaw/anatomy & histology Molecular Sequence Data Nuclear Proteins Phylogeny Pro-Opiomelanocortin/chemistry Sequence Alignment Sequence Deletion Sequence Homology, Amino Acid Transposases/chemistry,genetics Vertebrates/anatomy & histology,classification,genetics

Chemicals

DNA-Binding Proteins Homeodomain Proteins Nuclear Proteins RAG2 protein, human V(D)J recombination activating protein 2 RAG-1 protein Pro-Opiomelanocortin Transposases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Venkatesh B

Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore.

Erdmann M V

Brenner S

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.201415598

Published

2001-09-25

Epub

2001-00-11

Pages

11382-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC58738

Subset

Databases

GENBANK

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PubMed source DOI: 10.1073/pnas.201415598 PMC Full Text View journal details

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Molecular synapomorphies resolve evolutionary relationships of extant jawed vertebrates.

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