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PMID: 11543634 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

Genomics ·Vol. 77 ·No. 1-2 ·2001-09-00 ·Pages 65-70

Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T

Abstract

Mitochondria possess their own translational machinery, which is composed of components distinct from their cytoplasmic counterparts. To investigate the possible involvement of mitochondrial ribosomal defects in human disease, we mapped nuclear genes that encode mitochondrial ribosomal proteins (MRPs). We generated sequence-tagged sites (STSs) of individual MRP genes that were able to be detected by PCR. They were placed on an STS content map of the human genome by typing of radiation hybrid panels. We located 54 MRP genes on the STS-content map and assigned these genes to cytogenetic bands of the human chromosomes. Although mitochondria are thought to have originated from bacteria, in which the genes encoding ribosomal proteins are clustered into operons, the mapped MRP genes are widely dispersed throughout the genome, suggesting that transfer of each MRP gene to the nuclear genome occurred individually. We compared the assigned positions with candidate regions for mendelian disorders and found certain genes that might be involved in particular diseases. This map provides a basis for studying possible roles of MRP defects in mitochondrial disorders.

MeSH Terms

Chromosome Mapping Humans Mitochondria/metabolism Mitochondrial Diseases/genetics Molecular Sequence Data Ribosomal Proteins/genetics

Chemicals

Ribosomal Proteins

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Kenmochi N

Department of Biochemistry, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. kenmochi@med.u-ryukyu.ac.jp

Suzuki T

Uechi T

Magoori M

Kuniba M

Higa S

Watanabe K

Tanaka T

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1006/geno.2001.6622

kenmochi@med.u-ryukyu.ac.jp

Published

2001-09-00

Pages

65-70

Language

English

Region

United States

NLM ID

8800135

Subset

Databases

GENBANK

AB051336, AB051337, AB051338, AB051339, AB051340, AB051341, AB051342, AB051343, AB051344, AB051345, AB051346, AB051347, AB051348, AB051349, AB051350, AB051351, AB051352, AB051353, AB051354, AB051355, AB051617, AB051618, AB051619, AB051620, AB051621, AB051622, AB051623, AB051624, AB051625, AB051626, AB051627, AB051628, AB061206, AB061207, AB061208, AB061209, AB061210, AB061211, AB061314

External Links

PubMed source DOI: 10.1006/geno.2001.6622 View journal details

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The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

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