Effects of antagonists upon locomotor stimulation induced by injection of dopamine and Noradrenaline into the nucleus accumbens of nialamide-pretreated rats.

Psychopharmacologia ·Vol. 41 ·No. 2 ·1975-00-00 ·Pages 175-80

Pijnenburg AJ, Honig WM, Van Rossum JM

Abstract

The effects of injections of monoamines, alone and in combination with different antagonists, bilaterally into the nucleus accumbens of nialamide-pretreated rats were investigated. Dopamine was found to produce a stronger stimulation of locomotor activity than noradrenaline, whereas serotonin was effective only in a small number of animals, in which the duration of locomotor stimulation was shorter than after dopamine or noradrenaline. The effects of both dopamine and noradrenaline were completely antagonized by administration of a small dose of the dopamine antagonist haloperidol, administered bilaterally 15 min after the catecholamines. The alpha-adrenergic antagonist phentolamine did not inhibit the effect of noradrenaline but, on the contrary potentiated and considerably prolonged the duration of locomotor stimulation. Aslo, the effect of dopamine was potentiated and prolonged by phentolamine. Bilateral injection of phentolamine alone had no influence upon locomotor activity. The effect of noradrenaline was not clearly inhibited nor potentiated by the beta-adrenergic antagonist propranolol. It is suggested that the stimulation of locomotor activity induced by injection of noradrenaline into the uncleus accumbens of nialamide-pretreated rats is brought about via dopaminergic mechanisms.

MeSH Terms

Animals Dopamine/administration & dosage,pharmacology Dopamine Antagonists Haloperidol/pharmacology Injections Male Motor Activity/drug effects Nialamide/pharmacology Norepinephrine/administration & dosage,antagonists & inhibitors,pharmacology Olfactory Bulb/physiology Phentolamine/pharmacology Propranolol/pharmacology Rats

Chemicals

Dopamine Antagonists Propranolol Haloperidol Nialamide Dopamine Norepinephrine Phentolamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Pijnenburg A J

Honig W M

Van Rossum J M

References (22)

22 references, click to expand

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Article Info

Journal

Psychopharmacologia

Abbr.

Psychopharmacologia

DOI

10.1007/BF00421076

Published

1975-00-00

Pages

175-80

Language

English

Region

Germany

NLM ID

7609417

Subset

External Links

PubMed source DOI: 10.1007/BF00421076

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Effects of antagonists upon locomotor stimulation induced by injection of dopamine and Noradrenaline into the nucleus accumbens of nialamide-pretreated rats.

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