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PMID: 11532396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.

Current opinion in genetics & development ·Vol. 11 ·No. 5 ·2001-10-00 ·Pages 541-6

Callahan CA, Oro AE

Abstract

Epithelial organs such as the vertebrate hair control periodic self-renewal by regulating the growth of progenitor cells. Recent studies implicate Sonic hedgehog target gene induction in the growth of multipotent hair follicle epithelium and the development of a variety of hair follicle tumors such as basal cell carcinomas. These studies suggest Sonic hedgehog signaling may regulate progenitor cells in other organs.

MeSH Terms

Animals Bone Morphogenetic Proteins/metabolism Carrier Proteins Cell Differentiation Epithelium/metabolism,pathology Gene Expression Regulation, Developmental Hair Follicle/cytology,growth & development,metabolism,pathology Hedgehog Proteins Humans Proteins/metabolism Signal Transduction Skin Neoplasms/genetics,metabolism,pathology Stem Cells/cytology,metabolism Trans-Activators/genetics,metabolism Transcriptional Activation

Chemicals

Bone Morphogenetic Proteins Carrier Proteins Hedgehog Proteins Proteins SHH protein, human Trans-Activators noggin protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Callahan C A

Program in Epithelial Biology, Stanford University, CCSR Building, Room 2145, 269 Campus Drive, Stanford, CA 94305-5168, USA.

Oro A E

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(00)00230-6

Published

2001-10-00

Pages

541-6

Language

English

Region

England

NLM ID

9111375

Subset

Grants

NIAMS NIH HHS · AR46786 · United States

External Links

PubMed source DOI: 10.1016/s0959-437x(00)00230-6 View journal details

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Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.

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