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PMID: 11529883 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cell migration and organization in the intestinal crypt using a lattice-free model.

Cell proliferation ·Vol. 34 ·No. 4 ·2001-08-00 ·Pages 253-66

Meineke FA, Potten CS, Loeffler M

Abstract

We present a novel class of spatial models of cell movement and arrangement applied to the two-dimensional cellular organization of the intestinal crypt. The model differs from earlier approaches in using a dynamic movement on a lattice-free cylindrical surface. Cell movement is a consequence of mitotic activity. Cells interact by viscoelastic forces. Voronoi tessellation permits simulations of individual cell boundaries. Simulations can be compared with experimental data obtained from cell scoring in sections. Simulation studies show that the model is consistent with the experimental results for the spatial distribution of labelling indices, mitotic indices and other observed phenomena using a fixed number of stem cells and a fixed number of transit cell divisions.

MeSH Terms
Animals Cell Communication/physiology Cell Movement/physiology Computer Simulation Elasticity Intestinal Mucosa/cytology Male Mice Mitosis/physiology Models, Biological Paneth Cells/cytology Reproducibility of Results Viscosity
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Meineke F A
Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany. meineke@imise.uni-leipzig.de
Potten C S
Loeffler M
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Article Info
Journal
Cell proliferation
Abbr.
Cell Prolif
ISSN
0960-7722
DOI
10.1046/j.0960-7722.2001.00216.x
Email
meineke@imise.uni-leipzig.de
Published
2001-08-00
Pages
253-66
Language
English
Region
England
NLM ID
9105195
PMCID
PMC6495866
Subset
IM
External Links
PubMed source DOI: 10.1046/j.0960-7722.2001.00216.x PMC Full Text View journal details
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