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PMID: 11525814 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Single nucleotide polymorphisms and recombination rate in humans.

Trends in genetics : TIG ·Vol. 17 ·No. 9 ·2001-09-00 ·Pages 481-5

Nachman MW

Abstract

Levels of heterozygosity for single nucleotide polymorphisms vary by more than one order of magnitude in different regions of the human genome. Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level.

MeSH Terms

Evolution, Molecular Genetic Linkage Genetic Markers Genetic Variation Genetics, Population Genome Heterozygote Humans Models, Genetic Mutation Physical Chromosome Mapping Polymorphism, Single Nucleotide Recombination, Genetic X Chromosome/genetics

Chemicals

Genetic Markers

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nachman M W

Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA. nachmann@email.arizona.edu

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/s0168-9525(01)02409-x

nachmann@email.arizona.edu

Published

2001-09-00

Pages

481-5

Language

English

Region

England

NLM ID

8507085

Subset

External Links

PubMed source DOI: 10.1016/s0168-9525(01)02409-x View journal details

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