Home LiteratureArticle Details
PMID: 11502546 Published · ppublish English Journal Article

Multidrug-resistant strains of Neisseria gonorrhoeae in Greece.

Antimicrobial agents and chemotherapy ·Vol. 45 ·No. 9 ·2001-09-00 ·Pages 2651-4

Mavroidi A, Tzouvelekis LS, Kyriakis KP, Avgerinou H, Daniilidou M, Tzelepi E

Abstract

Eighty-seven out of 575 gonococci isolated in Greece from 1991 to 1998 belonged to serovar Bropyst and exhibited resistance to penicillin, tetracycline, erythromycin, and chloramphenicol. Conventional and molecular typing showed three clusters, A, B, and C, that were associated with networks of high- frequency transmitters (cluster A with homosexuals and clusters B and C with refugees from Eastern Europe). Study of one isolate revealed mutations in the penA, mtrR, and porB genes that may explain the multidrug-resistant phenotype.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacterial Outer Membrane Proteins/genetics Bacterial Proteins Chloramphenicol Resistance/genetics,physiology Drug Resistance, Microbial/genetics,physiology Drug Resistance, Multiple/genetics,physiology Erythromycin/pharmacology Ferredoxin-NADP Reductase Greece Humans Microbial Sensitivity Tests Mutation Neisseria gonorrhoeae/drug effects,genetics,physiology Penicillin Resistance/genetics,physiology Porins Repressor Proteins/genetics Tetracycline Resistance/genetics,physiology
Chemicals
Anti-Bacterial Agents Bacterial Outer Membrane Proteins Bacterial Proteins Porins Repressor Proteins porin protein, Neisseria mtrR protein, Neisseria gonorrhoeae Erythromycin methionine synthase reductase Ferredoxin-NADP Reductase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mavroidi A
National Reference Center for Neisseria gonorrhoeae, Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Tzouvelekis L S
Kyriakis K P
Avgerinou H
Daniilidou M
Tzelepi E
References (18)
18 references, click to expand
  1. The epidemiology of Neisseria gonorrhoeae in Europe.
    Microbes Infect. 1999 May;1(6):455-64 PMID: 10602678
  2. Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.
    Antimicrob Agents Chemother. 1999 Oct;43(10):2468-72 PMID: 10508026
  3. Characterization of Neisseria gonorrhoeae strains with decreased susceptibility to fluoroquinolones isolated in Greece from 1996 to 1999.
    J Clin Microbiol. 2000 Sep;38(9):3489-91 PMID: 10970412
  4. Rapid isolation of high molecular weight plant DNA.
    Nucleic Acids Res. 1980 Oct 10;8(19):4321-5 PMID: 7433111
  5. Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae.
    Mol Microbiol. 1989 Jan;3(1):35-41 PMID: 2497297
  6. The changing pattern of antibiotic resistance of Neisseria gonorrhoeae.
    Genitourin Med. 1990 Apr;66(2):55-6 PMID: 2111274
  7. Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.
    Mol Microbiol. 1990 Jun;4(6):913-9 PMID: 2120542
  8. The dominance of a multiresistant strain of Neisseria gonorrhoeae among prostitutes and STD patients in The Gambia.
    Genitourin Med. 1992 Dec;68(6):356-60 PMID: 1487255
  9. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids.
    Microbiology. 1995 Apr;141 ( Pt 4):907-11 PMID: 7773394
  10. Proposed criteria for interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin.
    Antimicrob Agents Chemother. 1995 Nov;39(11):2442-5 PMID: 8585723
  11. Antimicrobial agents and gonorrhoea: therapeutic choice, resistance and susceptibility testing.
    Genitourin Med. 1996 Aug;72(4):253-7 PMID: 8976828
  12. Antimicrobial susceptibility and types of Neisseria gonorrhoeae in Greece. Data for the period 1990 to 1993.
    Sex Transm Dis. 1997 Jul;24(6):378-85 PMID: 9243747
  13. Gonorrhea among men who have sex with men--selected sexually transmitted diseases clinics, 1993-1996.
    MMWR Morb Mortal Wkly Rep. 1997 Sep 26;46(38):889-92 PMID: 9315779
  14. Intercity spread of gonococci with decreased susceptibility to fluoroquinolones: a unique focus in the United States.
    J Infect Dis. 1998 Mar;177(3):677-82 PMID: 9498447
  15. Continuing evolution of the pattern of quinolone resistance in Neisseria gonorrhoeae isolated in Sydney, Australia.
    Sex Transm Dis. 1998 Sep;25(8):415-7 PMID: 9773433
  16. Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus.
    Antimicrob Agents Chemother. 1998 Nov;42(11):2799-803 PMID: 9797206
  17. Epidemiologic aspects of male gonococcal infection in Greece.
    Sex Transm Dis. 1999 Jan;26(1):43-8 PMID: 9918322
  18. Gonorrhea among men who have sex with men: outbreak caused by a single genotype of erythromycin-resistant Neisseria gonorrhoeae with a single-base pair deletion in the mtrR promoter region.
    J Infect Dis. 2000 Jun;181(6):2080-2 PMID: 10837198
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.45.9.2651-2654.2001
Published
2001-09-00
Pages
2651-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC90709
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.45.9.2651-2654.2001 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2