Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.

Antimicrobial agents and chemotherapy ·Vol. 7 ·No. 5 ·1975-05-00 ·Pages 606-13

Rattie ES, Ravin LJ

Abstract

Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. Pharmacokinetic parameters were calculated from the intravenous data based upon a two-compartment open model. The rate constants controlling the distribution between the central and peripheral compartments, the overall elimination rate constants, the apparent volumes of distribution, and the fraction of the dose in the central and peripheral compartments were determined. The bioavailability was calculated to be 100% for cefazolin and cephalothin.

MeSH Terms

Adult Cefazolin/administration & dosage,metabolism Cephalosporins/metabolism Cephalothin/administration & dosage,metabolism Humans Injections, Intramuscular Injections, Intravenous Kinetics

Chemicals

Cephalosporins Cefazolin Cephalothin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rattie E S

Ravin L J

References (12)

12 references, click to expand

Pharmacokinetics of the cephalosporins in healthy volunteers and uremic patients.
Postgrad Med J. 1971 Feb;47:Suppl:41-6 PMID: 5556189
Cefazolin, a new semisynthetic cephalosporin antibiotic. I. Synthesis and chemical properties of cefazolin.
J Antibiot (Tokyo). 1970 Mar;23(3):131-6 PMID: 5460274
Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.
J Pharm Sci. 1968 Jan;57(1):117-23 PMID: 5652110
Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity.
J Antibiot (Tokyo). 1970 Mar;23(3):137-48 PMID: 4394125
Serum and blood concentration of sodium cephalexin in man given single intramuscular and intravenous injections.
J Pharm Pharmacol. 1973 May;25(5):376-81 PMID: 4146392
Pharmacology of cefazolin in human volunteers.
J Clin Pharmacol. 1973 Aug-Sep;13(8):325-31 PMID: 4199213
Pharmacologic study of cefazolin in volunteers.
J Clin Pharmacol New Drugs. 1973 Feb-Mar;13(2):83-8 PMID: 4631139
Comparative serum levels and urinary recovery of cefazolin, cephaloridine, and cephalothin in man.
J Clin Pharmacol. 1974 Jan;14(1):61-6 PMID: 4588120
Cefazolin vs cephalothin and cephaloridine. A comparison of their clinical pharmacology.
Arch Intern Med. 1974 Mar;133(3):407-10 PMID: 4811478
Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.
Antimicrob Agents Chemother. 1972 Mar;1(3):221-34 PMID: 5045468
Cephalosporin antibiotics: therapeutic dimensions and future.
Postgrad Med J. 1971 Feb;47:Suppl:135-42 PMID: 5556185
Cefazolin, a new semisynthetic cephalosporin antibiotic. 3. Absorption, excretion and tissue distribution in parenteral administration.
J Antibiot (Tokyo). 1970 Apr;23(4):184-94 PMID: 5423363

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.7.5.606

Published

1975-05-00

Pages

606-13

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429190

Subset

External Links

PubMed source DOI: 10.1128/AAC.7.5.606 PMC Full Text View journal details

Analysis Services

Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.

Contact

WeChat Official Account