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PMID: 11465430 Published · ppublish English Journal Article

The preparation, characterization, and evaluation of cationic microparticles for DNA vaccine delivery.

Pharmaceutical research ·Vol. 18 ·No. 5 ·2001-05-00 ·Pages 709-12

Briones M, Singh M, Ugozzoli M, Kazzaz J, Klakamp S, Ott G, O'Hagan D

Abstract

暂无摘要

MeSH Terms
Animals Cations Cetrimonium Cetrimonium Compounds/chemistry DNA/chemistry Enzyme-Linked Immunosorbent Assay Female Gene Products, gag/immunology HIV Envelope Protein gp120/immunology Immunoglobulin G/biosynthesis Lactic Acid/chemistry Mice Mice, Inbred BALB C Microspheres Particle Size Plasmids/immunology Polyglycolic Acid/chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polymers/chemistry Protein Precursors/immunology Vaccines, DNA/administration & dosage,immunology
Chemicals
Cations Cetrimonium Compounds Gene Products, gag HIV Envelope Protein gp120 Immunoglobulin G Polymers Protein Precursors Vaccines, DNA p55 gag precursor protein, Human immunodeficiency virus 1 Polylactic Acid-Polyglycolic Acid Copolymer Polyglycolic Acid Lactic Acid DNA Cetrimonium
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Briones M
Chiron Technologies, Chiron Corporation, Emeryville, California 94608, USA.
Singh M
Ugozzoli M
Kazzaz J
Klakamp S
Ott G
O'Hagan D
References (22)
22 references, click to expand
  1. Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics.
    J Control Release. 1999 Sep 20;61(3):361-74 PMID: 10477808
  2. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation.
    Proc Natl Acad Sci U S A. 1999 May 25;96(11):6417-22 PMID: 10339602
  3. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination.
    Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9378-83 PMID: 9256490
  4. Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues.
    Proc Natl Acad Sci U S A. 1999 May 25;96(11):6411-6 PMID: 10339601
  5. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.
    Science. 1998 Oct 16;282(5388):476-80 PMID: 9774275
  6. Nanoparticle DNA carrier with poly(L-lysine) grafted polysaccharide copolymer and poly(D,L-lactic acid).
    Bioconjug Chem. 1997 Sep-Oct;8(5):735-42 PMID: 9327139
  7. DNA vaccines.
    Life Sci. 1997;60(3):163-72 PMID: 9000640
  8. Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA.
    Pharm Res. 1999 Apr;16(4):509-13 PMID: 10227704
  9. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses.
    Nat Med. 1998 Mar;4(3):365-8 PMID: 9500615
  10. Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene.
    J Virol. 2000 Mar;74(6):2628-35 PMID: 10684277
  11. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate.
    Adv Drug Deliv Rev. 1997 Oct 13;28(1):43-70 PMID: 10837564
  12. Heterologous protection against influenza by injection of DNA encoding a viral protein.
    Science. 1993 Mar 19;259(5102):1745-9 PMID: 8456302
  13. Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration.
    Vaccine. 1997 Jun;15(8):814-7 PMID: 9234522
  14. Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1.
    J Control Release. 2000 Jul 3;67(2-3):347-56 PMID: 10825566
  15. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients.
    Lancet. 1998 May 2;351(9112):1320-5 PMID: 9643795
  16. Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery.
    J Control Release. 2000 May 15;66(2-3):229-41 PMID: 10742583
  17. Biodegradation and biocompatibility of PLA and PLGA microspheres.
    Adv Drug Deliv Rev. 1997 Oct 13;28(1):5-24 PMID: 10837562
  18. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells.
    Gene Ther. 2000 Dec;7(24):2105-12 PMID: 11223992
  19. Enhancement of DNA vaccine potency using conventional aluminum adjuvants.
    Vaccine. 1999 Aug 20;18(1-2):18-28 PMID: 10501231
  20. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization.
    J Pharm Sci. 1999 Jan;88(1):126-30 PMID: 9874713
  21. Cationic microparticles: A potent delivery system for DNA vaccines.
    Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):811-6 PMID: 10639162
  22. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response.
    J Infect Dis. 1998 Jul;178(1):92-100 PMID: 9652427
Article Info
Journal
Pharmaceutical research
Abbr.
Pharm Res
ISSN
0724-8741
DOI
10.1023/a:1011053931523
Published
2001-05-00
Pages
709-12
Language
English
Region
United States
NLM ID
8406521
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1011053931523 View journal details
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