The essence of excitation.

Current opinion in cell biology ·Vol. 13 ·No. 4 ·2001-08-00 ·Pages 417-21

Reimer RJ, Fremeau RT, Bellocchio EE, Edwards RH

Abstract

The amino acid glutamate is the major excitatory neurotransmitter in a range of organisms from Caenorhabditis elegans to mammals, and it mediates the information processing that underlies essentially all behavior. Recent advances in our understanding of glutamate storage and release now illuminate how this ubiquitous amino acid can function as a signalling molecule.

MeSH Terms

ATP-Binding Cassette Transporters/metabolism Amino Acid Transport System X-AG Animals Carrier Proteins/metabolism Chloride Channels/metabolism Glutamic Acid/physiology Models, Biological Neurons/metabolism Proton Pumps/metabolism Signal Transduction Sodium-Phosphate Cotransporter Proteins Symporters Synaptic Vesicles/metabolism

Chemicals

ATP-Binding Cassette Transporters Amino Acid Transport System X-AG Carrier Proteins Chloride Channels Proton Pumps Sodium-Phosphate Cotransporter Proteins Symporters Glutamic Acid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Reimer R J

Departments of Neurology and Physiology, Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, University of California, San Francisco, School of Medicine, 513 Parnassus Avenue, 94143-0435, USA.

Fremeau R T

Bellocchio E E

Edwards R H

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(00)00230-1

Published

2001-08-00

Pages

417-21

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(00)00230-1 View journal details

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