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PMID: 11448985 Published · ppublish English Comment Journal Article Research Support, U.S. Gov't, P.H.S. Review

Nuclear pore complexes: dynamics in unexpected places.

The Journal of cell biology ·Vol. 154 ·No. 1 ·2001-07-09 ·Pages 17-20

Lyman SK, Gerace L

Abstract

In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.

MeSH Terms
Active Transport, Cell Nucleus Animals Basement Membrane/chemistry Cell Nucleus/metabolism Models, Biological Nuclear Envelope/metabolism Nuclear Pore/metabolism Nuclear Pore Complex Proteins Nuclear Proteins/chemistry
Chemicals
Nuclear Pore Complex Proteins Nuclear Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lyman S K
Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Gerace L
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200106071
Published
2001-07-09
Pages
17-20
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2196851
Subset
IM
Grants
NIGMS NIH HHS · R01 GM028521 · United States
NIGMS NIH HHS · R01 GM041955 · United States
NIGMS NIH HHS · GM28521 · United States
NIGMS NIH HHS · GM41955 · United States
Corrections
CommentOn
PMID: 11448991
External Links
PubMed source DOI: 10.1083/jcb.200106071 PMC Full Text View journal details
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