Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.

Animals Body Patterning DNA-Binding Proteins Drosophila Proteins Embryo, Mammalian/embryology,metabolism Embryonic Induction Epistasis, Genetic Gene Expression Regulation, Developmental Growth Differentiation Factor 1 Growth Substances/genetics Heart/embryology,physiology Hedgehog Proteins Homeobox Protein Nkx-2.5 Homeodomain Proteins/genetics In Situ Hybridization Intercellular Signaling Peptides and Proteins Membrane Proteins/genetics Mice Models, Biological Muscle Proteins/genetics Mutation/genetics Myogenic Regulatory Factor 5 Nerve Tissue Proteins/genetics Patched Receptors Patched-1 Receptor Proteins/genetics,metabolism RNA, Messenger/genetics,metabolism Receptors, Cell Surface/genetics,metabolism Receptors, G-Protein-Coupled Signal Transduction Smoothened Receptor Somites/metabolism Trans-Activators Transcription Factors/genetics Xenopus Proteins

CFC1 protein, human Cfc1 protein, mouse DNA-Binding Proteins Drosophila Proteins Gdf1 protein, mouse Growth Differentiation Factor 1 Growth Substances Hedgehog Proteins Homeobox Protein Nkx-2.5 Homeodomain Proteins Intercellular Signaling Peptides and Proteins Membrane Proteins Muscle Proteins Myf5 protein, mouse Myogenic Regulatory Factor 5 NKX2-5 protein, human Nerve Tissue Proteins Nkx2-5 protein, mouse Patched Receptors Patched-1 Receptor Proteins Ptch1 protein, mouse RNA, Messenger Receptors, Cell Surface Receptors, G-Protein-Coupled SHH protein, human Smo protein, mouse Smoothened Receptor Trans-Activators Transcription Factors Xenopus Proteins smo protein, Drosophila