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PMID: 11435606 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Deletion mapping of the encephalomyocarditis virus primary cleavage site.

Journal of virology ·Vol. 75 ·No. 15 ·2001-08-00 ·Pages 7215-8

Hahn H, Palmenberg AC

Abstract

The cotranslational, primary self-cleavage reaction of cardiovirus polyprotein relies on a highly conserved, short segment of amino acids at the 2A-2B protein boundary. The amino terminus of the required element for encephalomyocarditis virus has now been mapped to include Tyr(126) of the 2A protein, the 18th amino acid before the cleavage site.

MeSH Terms
Amino Acid Sequence Base Sequence Binding Sites Cysteine Endopeptidases/genetics,metabolism DNA, Viral Encephalomyocarditis virus/enzymology,genetics Molecular Sequence Data Mutagenesis Viral Proteins
Chemicals
DNA, Viral Viral Proteins Cysteine Endopeptidases picornain 2A, Picornavirus
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hahn H
Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin 53706, USA.
Palmenberg A C
References (15)
15 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.15.7215-7218.2001
Published
2001-08-00
Pages
7215-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114454
Subset
IM
Grants
NIGMS NIH HHS · GM-07215 · United States
NIGMS NIH HHS · T32 GM007215 · United States
NIAID NIH HHS · R01 AI017331 · United States
NIAID NIH HHS · AI-17331 · United States
NIAID NIH HHS · R56 AI017331 · United States
Databases
GENBANK
M81861
External Links
PubMed source DOI: 10.1128/JVI.75.15.7215-7218.2001 PMC Full Text View journal details
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