Mitotic kinases as regulators of cell division and its checkpoints.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 1 ·2001-01-00 ·Pages 21-32

Nigg EA

Abstract

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in the choreography of these processes can lead to aneuploidy or genetic instability, fostering cell death or disease. Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission.

MeSH Terms

Anaphase/physiology Animals CDC2 Protein Kinase/physiology Cell Division/physiology Chromosome Aberrations Chromosomes/physiology G2 Phase/physiology Humans Mitosis/physiology Neoplasms/enzymology,genetics,pathology Protein Kinases/physiology S Phase/physiology Signal Transduction Spindle Apparatus/physiology

Chemicals

Protein Kinases CDC2 Protein Kinase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nigg E A

Max-Planck-Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D-82152 Martinsried, Germany. nigg@biochem.mpg.de

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35048096

nigg@biochem.mpg.de

Published

2001-01-00

Pages

21-32

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35048096 View journal details

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Mitotic kinases as regulators of cell division and its checkpoints.

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