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PMID: 11413336 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pathogenesis of influenza A (H5N1) virus infection in a primate model.

Journal of virology ·Vol. 75 ·No. 14 ·2001-07-00 ·Pages 6687-91

Rimmelzwaan GF, Kuiken T, van Amerongen G, Bestebroer TM, Fouchier RA, Osterhaus AD

Abstract

Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

MeSH Terms
Animals Disease Models, Animal Fever/pathology Immunohistochemistry Influenza A Virus, H5N1 Subtype Influenza A virus/isolation & purification Lung Diseases, Interstitial/pathology,virology Macaca fascicularis Necrosis Orthomyxoviridae Infections/virology Respiratory Distress Syndrome/pathology Viscera/virology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rimmelzwaan G F
Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands.
Kuiken T
van Amerongen G
Bestebroer T M
Fouchier R A
Osterhaus A D
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.14.6687-6691.2001
Published
2001-07-00
Pages
6687-91
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114392
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.75.14.6687-6691.2001 PMC Full Text View journal details
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