A novel mechanism for inhibition of beta-oxidation by methylenecyclopropylacetyl-CoA, a metabolite of hypoglycin.

Acetyl Coenzyme A/analogs & derivatives,pharmacology Alanine/analogs & derivatives,metabolism Animals Butyrates/metabolism Carnitine/metabolism Coenzyme A/analogs & derivatives,metabolism Cyclopropanes/metabolism,pharmacology Fatty Acids/metabolism Kinetics Lipid Mobilization/drug effects Mitochondria, Liver/drug effects,metabolism Oxidoreductases/antagonists & inhibitors Oxygen Consumption/drug effects Rats Structure-Activity Relationship Time Factors Toxins, Biological/metabolism,pharmacology

Butyrates Cyclopropanes Fatty Acids Toxins, Biological Acetyl Coenzyme A Oxidoreductases Alanine Carnitine Coenzyme A