Abstract
We have examined the effect of an inhibitor of Rho-kinase, (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632), on the contractions elicited by noradrenergic nerve stimulation and by phenylephrine in the human and rabbit penile corpus cavernosum. In both tissues, after treatment with scopolamine (10 microM) and N(G)-nitro-L-arginine methyl ester (L-NAME; 300 microM), electrical field stimulation (EFS) elicited noradrenergic contractions. These contractions were inhibited by Y-27632 in a concentration-dependent manner. The compound caused concentration-dependent relaxation of phenylephrine-contracted tissues, which were treated with scopolamine (10 microM), guanethidine (10 microM) and L-NAME (300 microM). These results suggest that Rho-kinase is involved in noradrenergic contractile pathway in the cavernosal smooth muscle of the penis.
MeSH Terms
Amides/pharmacology
Animals
Drug Interactions
Electric Stimulation
Enzyme Inhibitors/pharmacology
Humans
In Vitro Techniques
Intracellular Signaling Peptides and Proteins
Male
Muscle Contraction/drug effects
Muscle Relaxants, Central/pharmacology
NG-Nitroarginine Methyl Ester/pharmacology
Penis/drug effects,physiology
Phenylephrine/pharmacology
Protein Serine-Threonine Kinases/antagonists & inhibitors
Pyridines/pharmacology
Rabbits
Synaptic Transmission/drug effects,physiology
Vasoconstrictor Agents/pharmacology
rho-Associated Kinases
Chemicals
Amides
Enzyme Inhibitors
Intracellular Signaling Peptides and Proteins
Muscle Relaxants, Central
Pyridines
Vasoconstrictor Agents
Y 27632
Phenylephrine
Protein Serine-Threonine Kinases
rho-Associated Kinases
NG-Nitroarginine Methyl Ester
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rees R W
The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6AE.
Ralph D J
Royle M
Moncada S
Cellek S
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