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PMID: 11395015 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe.

Neuron ·Vol. 30 ·No. 2 ·2001-05-00 ·Pages 569-81

Bazhenov M, Stopfer M, Rabinovich M, Abarbanel HD, Sejnowski TJ, Laurent G

Abstract

Locust antennal lobe (AL) projection neurons (PNs) respond to olfactory stimuli with sequences of depolarizing and hyperpolarizing epochs, each lasting hundreds of milliseconds. A computer simulation of an AL network was used to test the hypothesis that slow inhibitory connections between local neurons (LNs) and PNs are responsible for temporal patterning. Activation of slow inhibitory receptors on PNs by the same GABAergic synapses that underlie fast oscillatory synchronization of PNs was sufficient to shape slow response modulations. This slow stimulus- and neuron-specific patterning of AL activity was resistant to blockade of fast inhibition. Fast and slow inhibitory mechanisms at synapses between LNs and PNs can thus form dynamical PN assemblies whose elements synchronize transiently and oscillate collectively, as observed not only in the locust AL, but also in the vertebrate olfactory bulb.

MeSH Terms
Animals Grasshoppers/physiology Mechanoreceptors/physiology Models, Neurological Nerve Net/physiology Neurons/classification,physiology Odorants Oscillometry Reaction Time Receptors, GABA/physiology Receptors, Nicotinic/physiology Smell/physiology Synapses/physiology Synaptic Transmission/physiology gamma-Aminobutyric Acid/pharmacology,physiology
Chemicals
Receptors, GABA Receptors, Nicotinic gamma-Aminobutyric Acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bazhenov M
Howard Hughes Medical Institute, The Salk Institute, Computational Neurobiology Laboratory, La Jolla, CA 92037, USA. bazhenov@salk.edu
Stopfer M
Rabinovich M
Abarbanel H D
Sejnowski T J
Laurent G
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/s0896-6273(01)00286-0
Email
bazhenov@salk.edu
Published
2001-05-00
Pages
569-81
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC2907737
Subset
IM
Grants
Howard Hughes Medical Institute · United States
Corrections
CommentIn
PMID: 11394993
External Links
PubMed source DOI: 10.1016/s0896-6273(01)00286-0 PMC Full Text View journal details
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