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PMID: 11384837 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

Cellular signalling ·Vol. 13 ·No. 6 ·2001-06-00 ·Pages 389-400

Wajant H, Henkler F, Scheurich P

Abstract

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signalling pathways and are themselves often regulated at the transcriptional and posttranslational level. In this review, we address the structural and molecular basis of TRAF protein functions and highlight their role in cytokine signalling.

MeSH Terms
Animals Carrier Proteins/metabolism Enzyme Activation Humans Kinetics MAP Kinase Signaling System Membrane Glycoproteins/metabolism Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases/metabolism Models, Biological Multigene Family NF-kappa B/metabolism Protein Processing, Post-Translational Protein Serine-Threonine Kinases Protein Structure, Tertiary Proteins/chemistry Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-akt RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytokine/metabolism Receptors, Tumor Necrosis Factor/genetics,physiology Signal Transduction TNF Receptor-Associated Factor 1 Transcription, Genetic Tumor Necrosis Factor-alpha/metabolism
Chemicals
Carrier Proteins Membrane Glycoproteins NF-kappa B Proteins Proto-Oncogene Proteins RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytokine Receptors, Tumor Necrosis Factor TNF Receptor-Associated Factor 1 TNFRSF11A protein, human TNFSF11 protein, human Tumor Necrosis Factor-alpha Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wajant H
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. harld.wajant@po.uni-stuttgart.de
Henkler F
Scheurich P
Article Info
Journal
Cellular signalling
Abbr.
Cell Signal
ISSN
0898-6568
Published
2001-06-00
Pages
389-400
Language
English
Region
England
NLM ID
8904683
Subset
IM
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