Abstract
The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signalling pathways and are themselves often regulated at the transcriptional and posttranslational level. In this review, we address the structural and molecular basis of TRAF protein functions and highlight their role in cytokine signalling.
MeSH Terms
Animals
Carrier Proteins/metabolism
Enzyme Activation
Humans
Kinetics
MAP Kinase Signaling System
Membrane Glycoproteins/metabolism
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases/metabolism
Models, Biological
Multigene Family
NF-kappa B/metabolism
Protein Processing, Post-Translational
Protein Serine-Threonine Kinases
Protein Structure, Tertiary
Proteins/chemistry
Proto-Oncogene Proteins/metabolism
Proto-Oncogene Proteins c-akt
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Receptors, Cytokine/metabolism
Receptors, Tumor Necrosis Factor/genetics,physiology
Signal Transduction
TNF Receptor-Associated Factor 1
Transcription, Genetic
Tumor Necrosis Factor-alpha/metabolism
Chemicals
Carrier Proteins
Membrane Glycoproteins
NF-kappa B
Proteins
Proto-Oncogene Proteins
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Receptors, Cytokine
Receptors, Tumor Necrosis Factor
TNF Receptor-Associated Factor 1
TNFRSF11A protein, human
TNFSF11 protein, human
Tumor Necrosis Factor-alpha
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wajant H
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. harld.wajant@po.uni-stuttgart.de
Henkler F
Scheurich P