Globin synthesis in subjects doubly heterozygous for hemoglobin G-Philadelphia and hemoglobin S or C.

The Journal of laboratory and clinical medicine ·Vol. 85 ·No. 6 ·1975-06-00 ·Pages 891-7

McCurdy PR, Sherman AS, Kamuzora H, Lehmann H

Abstract

To study the function of globin-chain genes, in vitro synthesis of globin was measured in reticulocytes concentrated from the peripheral blood of 7 subjects doubly heterozygous for an alpha-chain abnormality (Hb G-Philadelphia) and a beta-chain abnormality (Hb S or C). Each had a deficit of alpha-chain synthesis compatible with an alpha-thalassemia-like syndrome. The data are also compatible with the quantitative expression of variable reduplication of the alpha-chain locus in man.

MeSH Terms

African Americans Alleles Anemia/blood Carbon Radioisotopes Erythrocytes, Abnormal/analysis Female Globins/biosynthesis Hematocrit Hemoglobin C/analysis Hemoglobin, Sickle/analysis Hemoglobinopathies/genetics Hemoglobins/analysis Hemoglobins, Abnormal/metabolism Heterozygote Humans In Vitro Techniques Male Middle Aged Reticulocytes/analysis United States

Chemicals

Carbon Radioisotopes Hemoglobin, Sickle Hemoglobins Hemoglobins, Abnormal Globins Hemoglobin C

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

McCurdy P R

Sherman A S

Kamuzora H

Lehmann H

Article Info

Journal

The Journal of laboratory and clinical medicine

Abbr.

J Lab Clin Med

ISSN

0022-2143

Published

1975-06-00

Pages

891-7

Language

English

Region

United States

NLM ID

0375375

Subset

External Links

PubMed source

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Globin synthesis in subjects doubly heterozygous for hemoglobin G-Philadelphia and hemoglobin S or C.

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