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PMID: 11371643 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Developmental plasticity of CNS microglia.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 11 ·2001-05-22 ·Pages 6295-300

Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P, Stern LJ, Strominger JL, Riese R

Abstract

Microglia arise from CD45(+) bone marrow precursors that colonize the fetal brain and play a key role in central nervous system inflammatory conditions. We report that parenchymal microglia are uncommitted myeloid progenitors of immature dendritic cells and macrophages by several criteria, including surface expression of "empty" class II MHC protein and their cysteine protease (cathepsin) profile. Microglia express receptors for stem cell factor and can be skewed toward more dendritic cell or macrophage-like profiles in response to the lineage growth factors granulocyte/macrophage colony-stimulating factor or macrophage colony-stimulating factor. Thus, in contrast to other organs, where terminally differentiated populations of resident dendritic cells and/or macrophages outnumber colonizing precursors, the majority of microglia within the brain remain in an undifferentiated state.

MeSH Terms
Animals Cathepsins/genetics,immunology Cell Differentiation Cells, Cultured Central Nervous System/cytology,immunology Dendritic Cells/immunology Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology Hematopoietic Stem Cells/cytology,immunology Histocompatibility Antigens Class II/immunology Interferon-gamma/immunology,pharmacology Macrophages/immunology Membrane Proteins/biosynthesis Mice Microglia/cytology,drug effects,immunology Neuronal Plasticity/immunology Stem Cell Factor/biosynthesis
Chemicals
Histocompatibility Antigens Class II Membrane Proteins Stem Cell Factor flt3 ligand protein Interferon-gamma Granulocyte-Macrophage Colony-Stimulating Factor Cathepsins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Santambrogio L
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA. laura_santambrogio@dfci.harvard.edu
Belyanskaya S L
Fischer F R
Cipriani B
Brosnan C F
Ricciardi-Castagnoli P
Stern L J
Strominger J L
Riese R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.111152498
Email
laura_santambrogio@dfci.harvard.edu
Published
2001-05-22
Pages
6295-300
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33462
Subset
IM
Grants
NIAID NIH HHS · R01 AI038996 · United States
NCI NIH HHS · R01-CA67416 · United States
NIAID NIH HHS · K08-AI01555 · United States
NCI NIH HHS · 5R35-CA47554 · United States
NIAID NIH HHS · R01-AI38996 · United States
NIAID NIH HHS · N01-AI45198 · United States
External Links
PubMed source DOI: 10.1073/pnas.111152498 PMC Full Text View journal details
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