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PMID: 11358893 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils.

Gut ·Vol. 48 ·No. 6 ·2001-06-00 ·Pages 765-73

Takashima M, Furuta T, Hanai H, Sugimura H, Kaneko E

Abstract

Body gastritis caused by Helicobacter pylori infection appears to inhibit gastric acid secretion. The aim of this study was to determine the effects of H pylori infection on gastric acid secretion and clarify its mechanisms with reference to interleukin 1beta (IL-1beta). (1) Mongolian gerbils were inoculated orally with H pylori. Before, six, and 12 weeks after inoculation, serum gastrin levels, gastric acid output, and IL-1beta mRNA levels in the gastric mucosa were determined. Pathological changes were also determined according to the updated Sydney system. (2) Effects of recombinant human IL-1 receptor antagonist (rhIL-1ra) on gastric acid output and serum gastrin levels were also determined. (1) Scores for activity and inflammation of gastritis and serum gastrin levels were significantly increased, and gastric acid output was significantly decreased six and 12 weeks after inoculation with H pylori. IL-1beta mRNA levels in the gastric mucosa were also elevated six and 12 weeks after inoculation with H pylori. (2) Acid output and serum gastrin levels in the infected groups returned to control levels after rhIL-1ra injection. Gastric acid secretion is decreased and serum gastrin levels are increased in Mongolian gerbils infected with H pylori. This change in gastric acid secretion appears to be mediated by IL-1beta induced by H pylori infection.

MeSH Terms
Analysis of Variance Animals Electrophoresis, Agar Gel Gastric Acid/metabolism Gastric Mucosa/metabolism Gastrins/analysis,metabolism Gastritis/metabolism,microbiology Gerbillinae Helicobacter Infections/complications,metabolism,pathology Helicobacter pylori Interleukin-1/analysis,genetics,metabolism Male Neutrophil Infiltration RNA, Messenger/analysis Receptors, Interleukin-1/antagonists & inhibitors,metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Specific Pathogen-Free Organisms Statistics, Nonparametric
Chemicals
Gastrins Interleukin-1 RNA, Messenger Receptors, Interleukin-1
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Takashima M
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. takam@h7.dion.ne.jp
Furuta T
Hanai H
Sugimura H
Kaneko E
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.48.6.765
Email
takam@h7.dion.ne.jp
Published
2001-06-00
Pages
765-73
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1728329
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.48.6.765 PMC Full Text View journal details
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