Induction of HIF-1alpha in response to hypoxia is instantaneous.

Carbon-Oxygen Lyases/metabolism Cell Hypoxia/physiology DNA-(Apurinic or Apyrimidinic Site) Lyase DNA-Binding Proteins/genetics,metabolism Gene Expression Regulation HeLa Cells Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Immunoblotting Kinetics NF-kappa B/metabolism Nuclear Proteins/genetics,metabolism Oxygen/metabolism Proto-Oncogene Proteins c-fos/metabolism Proto-Oncogene Proteins c-jun/metabolism Thioredoxins/metabolism Time Factors Transcription Factors/genetics,metabolism

DNA-Binding Proteins HIF1A protein, human Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit NF-kappa B Nuclear Proteins Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun Transcription Factors Thioredoxins Carbon-Oxygen Lyases APEX1 protein, human DNA-(Apurinic or Apyrimidinic Site) Lyase Oxygen