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PMID: 11343902 Published · ppublish English Journal Article Review

mRNA turnover.

Current opinion in cell biology ·Vol. 13 ·No. 3 ·2001-06-00 ·Pages 320-5

Mitchell P, Tollervey D

Abstract

Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the mature mRNP structure is established and is monitored by mRNA surveillance systems. Competition for the cap structure links translation and subsequent mRNA degradation, which may also involve multiple deadenylases.

MeSH Terms
Alternative Splicing/physiology Animals Peptide Chain Initiation, Translational/physiology Protein Biosynthesis/physiology RNA Precursors/metabolism RNA, Messenger/metabolism Ribonucleases/metabolism Ribonucleoproteins/metabolism Yeasts/metabolism
Chemicals
RNA Precursors RNA, Messenger Ribonucleoproteins messenger ribonucleoprotein Ribonucleases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mitchell P
Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Kings' Buildings, Edinburgh EH9 3JR, UK. pmitch@holyrood.ed.ac.uk
Tollervey D
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
Published
2001-06-00
Pages
320-5
Language
English
Region
England
NLM ID
8913428
Subset
IM
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