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PMID: 11340207 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Vital involvement of a natural killer cell activation receptor in resistance to viral infection.

Science (New York, N.Y.) ·Vol. 292 ·No. 5518 ·2001-05-04 ·Pages 934-7

Brown MG, Dokun AO, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, Dubbelde CE, Stone LR, Scalzo AA, Yokoyama WM

Abstract

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Antigens, Ly Crosses, Genetic Cytotoxicity, Immunologic Female Haplotypes Herpesviridae Infections/immunology Histocompatibility Antigens Class I/immunology Humans Immunity, Innate Killer Cells, Natural/immunology Lectins, C-Type Ligands Lymphocyte Activation Male Membrane Glycoproteins/genetics,immunology Mice Mice, Inbred C57BL Mice, Inbred DBA Muromegalovirus/immunology Phenotype Receptors, Immunologic/immunology Receptors, NK Cell Lectin-Like Tumor Cells, Cultured

Chemicals

Antibodies, Monoclonal Antigens, Ly Histocompatibility Antigens Class I Lectins, C-Type Ligands Membrane Glycoproteins Receptors, Immunologic Receptors, NK Cell Lectin-Like

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Brown M G

Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.

Dokun A O

Heusel J W

Smith H R

Beckman D L

Blattenberger E A

Dubbelde C E

Stone L R

Scalzo A A

Yokoyama W M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1060042

Published

2001-05-04

Pages

934-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1060042 View journal details

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Vital involvement of a natural killer cell activation receptor in resistance to viral infection.

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