The cellular neurobiology of depression.

Nature medicine ·Vol. 7 ·No. 5 ·2001-05-00 ·Pages 541-7

Manji HK, Drevets WC, Charney DS

Abstract

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

MeSH Terms

Antidepressive Agents/pharmacology,therapeutic use Cell Survival/drug effects Depressive Disorder/drug therapy,metabolism,pathology Glucocorticoids/pharmacology Neuronal Plasticity/drug effects Signal Transduction

Chemicals

Antidepressive Agents Glucocorticoids

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Manji H K

Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA. manjih@intra.nimh.nih.gov

Drevets W C

Charney D S

Article Info

Journal

Nature medicine

Abbr.

Nat Med

ISSN

1078-8956

DOI

10.1038/87865

manjih@intra.nimh.nih.gov

Published

2001-05-00

Pages

541-7

Language

English

Region

United States

NLM ID

9502015

Subset

External Links

PubMed source DOI: 10.1038/87865 View journal details

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The cellular neurobiology of depression.

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