Abstract
Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform, provides the necessary accuracy and produces reliable as well as rapid quantification results. But accurate quantification of nucleic acids requires a reproducible methodology and an adequate mathematical model for data analysis. This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript. Therefore, a new mathematical model is presented. The relative expression ratio is calculated only from the real-time PCR efficiencies and the crossing point deviation of an unknown sample versus a control. This model needs no calibration curve. Control levels were included in the model to standardise each reaction run with respect to RNA integrity, sample loading and inter-PCR variations. High accuracy and reproducibility (<2.5% variation) were reached in LightCycler PCR using the established mathematical model.
MeSH Terms
Animals
DNA Primers
Gene Expression Regulation
Models, Theoretical
RNA, Messenger/analysis
Reference Standards
Reproducibility of Results
Reverse Transcriptase Polymerase Chain Reaction/standards
Sensitivity and Specificity
Time Factors
Transcription, Genetic
Chemicals
DNA Primers
RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pfaffl M W
Institute of Physiology, FML-Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany. pfaffl@weihenstephan.de
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