Defective innervation of heart in diabetic autonomic neuropathy.

British medical journal ·Vol. 3 ·No. 5974 ·1975-07-05 ·Pages 15-7

Lloyd-Mostyn RH, Watkins PJ

Abstract

Heart rate responses to autonomic stimulation and inhibition were studied in 13 diabetic autonomic neuropathy. Parasympathetic function was impaired in all patients and sympathetic function in most. One patient's heart appeared to be totally denervated. The consequences of cardiac denervation include tachycardia, a fixed heart rate, and a possible tendency to cardiac dysrhythmias, which caused spontaneous cardiac arrests in three patients.

MeSH Terms

Adult Amyl Nitrite/pharmacology Atropine/pharmacology Autonomic Nervous System/physiopathology Blood Pressure Diabetic Neuropathies/complications,physiopathology Female Heart/innervation Heart Arrest/etiology Heart Rate Humans Lobeline/pharmacology Male Middle Aged Parasympathetic Nervous System/physiopathology Phenylephrine/pharmacology Posture Propranolol/pharmacology Stress, Psychological Sympathetic Nervous System/physiopathology Tachycardia/etiology Valsalva Maneuver

Chemicals

Phenylephrine Atropine Amyl Nitrite Propranolol Lobeline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lloyd-Mostyn R H

Watkins P J

References (13)

13 references, click to expand

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Absent circulatory reflexes in diabetic neuritis.
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Lancet. 1953 Mar 21;1(6760):560-5 PMID: 13036076
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Effects of autonomic blockade on the baroreflex in man at rest and during exercise.
Circ Res. 1972 Feb;30(2):177-85 PMID: 4400823
Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity.
Circ Res. 1969 Jan;24(1):109-21 PMID: 4303309
Cardiac denervation in diabetes.
Br Med J. 1973 Dec 8;4(5892):584-6 PMID: 4758519
Hemodynamic performance of the transplanted human heart.
Surgery. 1971 Jul;70(1):88-96 PMID: 4933443
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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5974.15

Published

1975-07-05

Pages

15-7

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1673690

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5974.15 PMC Full Text

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