HMG-1 rediscovered as a cytokine.

Shock (Augusta, Ga.) ·Vol. 15 ·No. 4 ·2001-04-00 ·Pages 247-53

Yang H, Wang H, Tracey KJ

Abstract

High-mobility group-1 (HMG-1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, facilitates gene transcription, and regulates the activity of steroid hormone receptors. We discovered that HMG-1 is a late mediator of delayed endotoxin lethality. When released by activated monocytes, it participates in the development of lethality and it activates downstream cytokine release. This review covers the general features of HMG-1 and its newly appreciated role as a cytokine.

MeSH Terms

Acute-Phase Reaction/etiology Amino Acid Sequence Animals Carrier Proteins/blood,chemistry,genetics,physiology,toxicity Cytokines/physiology Drosophila melanogaster/metabolism Endotoxemia/metabolism Endotoxins/pharmacology,toxicity HMGB1 Protein High Mobility Group Proteins/blood,chemistry,genetics,physiology,toxicity Humans Inflammation Mediators/metabolism Insect Proteins/chemistry,physiology Interleukin-1/pharmacology Lung/metabolism,pathology Macrophages/drug effects Models, Biological Molecular Sequence Data Monocytes/drug effects,metabolism Multigene Family Pituitary Gland, Anterior/cytology Protein Processing, Post-Translational Receptor for Advanced Glycation End Products Receptors, Immunologic/metabolism Shock, Septic/etiology,metabolism Signal Transduction/drug effects,physiology Species Specificity Tumor Necrosis Factor-alpha/pharmacology Vertebrates/metabolism

Chemicals

Carrier Proteins Cytokines Endotoxins HMGB1 Protein High Mobility Group Proteins Inflammation Mediators Insect Proteins Interleukin-1 Receptor for Advanced Glycation End Products Receptors, Immunologic Tumor Necrosis Factor-alpha

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Yang H

Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York 11030, USA.

Wang H

Tracey K J

Article Info

Journal

Shock (Augusta, Ga.)

Abbr.

Shock

ISSN

1073-2322

DOI

10.1097/00024382-200115040-00001

Published

2001-04-00

Pages

247-53

Language

English

Region

United States

NLM ID

9421564

Subset

External Links

PubMed source DOI: 10.1097/00024382-200115040-00001 View journal details

Analysis Services

HMG-1 rediscovered as a cytokine.

Contact

WeChat Official Account