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PMID: 11287589 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor.

Journal of virology ·Vol. 75 ·No. 9 ·2001-05-00 ·Pages 4399-401

Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y

Abstract

Both CD46 and signaling lymphocytic activation molecule (SLAM) have been shown to act as cellular receptors for measles virus (MV). The viruses on throat swabs from nine patients with measles in Japan were titrated on Vero cells stably expressing human SLAM. Samples from all but two patients produced numerous plaques on SLAM-expressing Vero cells, whereas none produced any plaques on Vero cells endogenously expressing CD46. The Edmonston strain of MV, which can use either CD46 or SLAM as a receptor, produced comparable titers on these two types of cells. The results strongly suggest that the viruses in the bodies of measles patients use SLAM but probably not CD46 as a cellular receptor.

MeSH Terms
Animals Antigens, CD/genetics,metabolism CHO Cells Chlorocebus aethiops Cricetinae Glycoproteins/genetics,metabolism Humans Immunoglobulins/genetics,metabolism Measles/virology Measles virus/metabolism,physiology Membrane Cofactor Protein Membrane Glycoproteins/genetics,metabolism Pharynx/virology Receptors, Cell Surface Receptors, Virus/genetics,metabolism Signaling Lymphocytic Activation Molecule Family Member 1 Vero Cells Viral Plaque Assay
Chemicals
Antigens, CD CD46 protein, human Glycoproteins Immunoglobulins Membrane Cofactor Protein Membrane Glycoproteins Receptors, Cell Surface Receptors, Virus Signaling Lymphocytic Activation Molecule Family Member 1
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ono N
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
Tatsuo H
Hidaka Y
Aoki T
Minagawa H
Yanagi Y
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.9.4399-4401.2001
Published
2001-05-00
Pages
4399-401
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114185
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.75.9.4399-4401.2001 PMC Full Text View journal details
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