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PMID: 1128665 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

Nature ·Vol. 255 ·No. 5503 ·1975-05-01 ·Pages 28-33

Adams JM, Cory S

Abstract

Messenger RNAs from mouse myeloma cells contain N-6-methyl adenosine and novel 5' termini having 7-methy-guanosine in a 5', 5' triphosphate linkage with ribose-methylated nucleosides. Ten common 5'-terminal sequences of the forms m-7-G-5'-PPP-5'-NmpNp and m-7-G-5'-ppp-5'-NmpNmpNp are reported. Structures like this may be a general feature of mRNA in eukaryotes.

MeSH Terms

Adenine Nucleotides/analysis Adenosine/analysis Animals Autoradiography Base Sequence Cell Line Electrophoresis Guanosine/analysis Mice Multiple Myeloma/analysis Nucleosides/analysis Polynucleotides/analysis RNA, Messenger/analysis RNA, Neoplasm/analysis RNA, Ribosomal/analysis RNA, Transfer/analysis

Chemicals

Adenine Nucleotides Nucleosides Polynucleotides RNA, Messenger RNA, Neoplasm RNA, Ribosomal Guanosine RNA, Transfer Adenosine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Adams J M

Cory S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/255028a0

Published

1975-05-01

Pages

28-33

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/255028a0 View journal details

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Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

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